• Immune Complex®
  • Immune Complex®

Immune Complex®

  • $22.00
  • - 0%
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Why take Immune Complex?

🧬 Contributes To The Maintenance Of A Healthy Immune system

Twenty First Century Herbs Vegan Friendly Food Supplements

What Is Immune Complex®?

Immune complex® consists of synergistic blend of bioavailable vitamins C and D along with vitamin A, vitamin B6, vitamin B12, folic acid, iron, zinc and copper. These ingredients work together to maintain the normal functioning of our immune system healthy which provides the differentiating element that make this supplement the right option for maintaining the normal functioning of our defences. The benefits of immune complex® includes optimal inflammatory response, effective prevention from infections and diseases especially autoimmune diseases, improved innate and adaptive immunity and effective immune cell proliferation.

Vitamin A:
Vitamin A plays a vital role in maintaining the body’s natural defenses. This includes the mucous barriers in your eyes, lungs, gut and genitals which help trap bacteria and other infectious agents. It’s also involved in the production and function of white blood cells, which help capture and clear bacteria and other pathogens from your bloodstream. Infectious diseases that induce the acute-phase response also impair the assessment of vitamin A status by transiently depressing serum retinol concentrations. Vitamin A deficiency impairs innate immunity by impeding normal regeneration of mucosal barriers damaged by infection, and by diminishing the function of neutrophils, macrophages, and natural killer cells. Vitamin A is also required for adaptive immunity and plays a role in the development of T both-helper (Th) cells and B-cells. Vitamin A deficiency diminishes antibody-mediated responses directed by Th2 cells, although some aspects of Th1-mediated immunity are also diminished. These changes in mucosal epithelial regeneration and immune function presumably account for the increased mortality seen in vitamin A-deficient infants, young children, and pregnant women in many areas of the world today.

Vitamin D:
Vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells, and antigen-presenting cells), and these immunologic cells are all capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity and an increased susceptibility to infection. As immune cells in autoimmune diseases are responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin D-deficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis.

Vitamin C:
Vitamin C contributes to immune defence by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene regulating effects. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections.

Vitamin B6:
Vitamin B6 deficiency affects both humoral and cell-mediated immune responses. Lymphocyte differentiation and maturation are altered by deficiency, delayed-type hypersensitivity responses are reduced, and antibody production may be indirectly impaired. Although repletion of the vitamin restores these functions, megadoses do not produce benefits beyond those observed with moderate supplementation. Additional human studies indicate that vitamin B6 status may influence tumor growth and disease processes. Deficiency of the vitamin has been associated with immunological changes observed in the elderly, persons infected with human immunodeficiency virus (HIV), and those with uremia or rheumatoid arthritis.
Folic acid:
Inadequate levels of folic acid can drastically alter immune responses by affecting the production of nucleic acid, protein synthesis, inhibiting the activity of immune cells, and interfering with metabolic processes, including methylation and serine, glycine, and purine cycles. Inefficient methylation can lead to hyperhomocysteinemia which causes systemic and vascular inflammation contributing to the pathogenesis of many other diseases.

Vitamin B12:
In addition to those numerous functions, vitamin B12 also offers critical immune system support. Cells in a strong immune system thrive on oxygen, which is delivered via red blood cells. Vitamin B12 is integral to red blood cell production, ensuring the immune system gets the oxygen it needs. Because of this, a B12 deficiency can interrupt the intricate processes involved in immunity, weakening your body’s defence system against disease. Therefore, it’s important to get enough B12 for immune system support and recognize the signs of a deficiency.

Experimental evidence in the last decades show that iron is a fundamental element for normal development of the immune system. Its deficiency affects the capacity to have an adequate immune response. The role of iron in immunity is necessary for immune cells proliferation and maturation, particularly lymphocytes, associated with the generation of a specific response to infection. The body has capacity to reduce the iron availability to be consumed by infectious elements by proteins such as transferrin and lactoferrin. Also, iron is essential for the proliferation of bacteria, parasites, and neoplastic cells. Thus excess iron could potentially facilitate the development of infections and the invasion of tumoral cells. The immune system has bacteriostatic mechanisms that reduce the availability of the metal, interfering with bacterial growth.

Zinc is crucial for normal development and function of cells mediating nonspecific immunity such as neutrophils and natural killer cells. Zinc deficiency also affects development of acquired immunity by preventing both the outgrowth and certain functions of T lymphocytes such as activation, Th1 cytokine production, and B lymphocyte help. Likewise, B lymphocyte development and antibody production, particularly immunoglobulin G, is compromised. The macrophage, a pivotal cell in many immunologic functions, is adversely affected by zinc deficiency, which can dysregulate intracellular killing, cytokine production, and phagocytosis. The effects of zinc on these key immunologic mediators is rooted in the myriad roles for zinc in basic cellular functions such as DNA replication, RNA transcription, cell division, and cell activation. Apoptosis is potentiated by zinc deficiency. Zinc also functions as an antioxidant and can stabilize membranes.

Some of the recent research showed that interleukin 2 is reduced in copper deficiency and is likely the mechanism by which T cell proliferation is reduced. These results were extended to show that even in marginal deficiency, when common indexes of copper are not affected by the diet, the proliferative response and interleukin concentrations are reduced. The number of neutrophils in human peripheral blood is reduced in cases of severe copper deficiency. Not only are they reduced in number, but their ability to generate superoxide anion and kill ingested microorganisms is also reduced in both overt and marginal copper deficiency. This mechanism is not yet understood. Neutrophil-like HL-60 cells accumulate copper as they differentiate into a more mature cell population and this accumulation is not reflected by increases in Cu/Zn superoxide dismutase or cytochrome-c oxidase activities.

Proudly Made In The UK Rhubarb Complex
Proudly Made In The UK

      Testimonials & Reviews - The views expressed above are the opinion of Twenty First Century Herbs customers. Twenty First Century Herbs does not endorse these views, nor should they be regarded as health claims or medical advice.

      How do I take it?

      Our Immune Complex® has been designed so that you take 1 capsule per day, just before breakfast or lunch. 

      Is this safe to take long term?

      Yes, our formula is designed to be taken during everyday life and can provide natural constipation relief, together with a gentle daily detox to help rid the body of impurities. All our customers, including ourselves, take Rhubarb Complex whilst working, socialising or travelling without any problems whatsoever.

      Can I take it alongside any medication?

      Yes, there are no contraindications with any medication.


      Are the supplements Vegan & Vegetarian friendly?

      Yes, all our products are vegan and vegetarian friendly. Our ingredients are 100% natural and have been handpicked by leading herbalists, based on 85 years of expertise.

      Are the capsules Gluten Free?




       Nutritional Information Per Serving (1 Capsule) % Reference Intake
      Vitamin A 800μg 100%
      Vitamin D 5μg 100%
      Vitamin C 80mg 100%
      Vitamin B6 1.4mg 100%
      Folic Acid 200μg 100%
      Vitamin B12 2.5μg 100%
      Iron 14mg 100%
      Zinc 10mg 100%
      Copper 1mg 100%
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